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Schools and some markets will be allowed to re-open, Chilufya told a news conference in Lusaka on 14 January.
The outbreak has killed 74 people since Oct. 4, including 68 in Lusaka, Chilufya said.
The number of new cases has fallen to around 80 from 164 a week ago. Of the more than 3,200 cases reported in total, more than 3,000 have been in Lusaka.
All government and private schools will re-open on 22 January but Zambia’s two largest public universities will remain closed for now.
President Edgar Lungu last month directed the military to clean markets and unblock drains to help to fight the spread of the waterborne disease.